Dose Increases on Foundayo: What to Expect
Foundayo (orforglipron) is a once-daily tablet that starts at 0.8 mg, and its UK licence allows the dose to be increased in stages at least 30 days apart, from 2.5 mg to 5.5 mg and on to optional higher strengths. For many people taking it, each of those steps becomes a small event of its own: anticipated for days beforehand, then watched closely once it arrives.
What follows draws on public forum threads where people compare notes on those steps. They are personal accounts, not evidence of how often anything happens or why, and most come from US forums, with a smaller number of UK voices.
The picture they paint is of a step that is rarely the same twice. Some people are braced for a rough few days, some barely notice, and some are weighing up whether to take the next step at all.
The Jump That Gets People Talking
The first move, from 0.8 mg to 2.5 mg, draws the most commentary, partly because it roughly triples the strength on paper and there is nothing in between.
"This 2.5mg is a massive difference from the 0.8mg dosage, it’s scary to think there are even higher dosages! I wonder why Elly Lilly made such a drastic change from the 0.8 to 2.5. Why not 1.50? […]"
– OahuHawaiiUSA
For people who have not yet made the move, the size of the step turns into anticipation and, in some cases, dread.
"I move up to 2.5 in a couple of days and now I’m scared! I’ve had low grade nausea at .8 and for the first three weeks was so tired I could hardly keep my eyes open. […]"
– krispdx
Others plan around it, treating the first day on a new strength as something that has to fit into the diary.
"No prior GLP, 3rd week on .8mg & its going well. Minor nausea day1 and gastro issue after a bad choice fried meal another day. Ready to move to 2.5mg BUT that day 1 would conflict with a big bday for me so I'd like to avoid that, if possible. […]"
– Designer-Major5842
The First Few Days
What happens once the new strength starts varies more than the build-up suggests. One person who had sailed through the first month found the change abrupt.
"I had zero issues with 0.8 - sailed through the month. No side effects, no weight loss either. Just started 2.5 last week and it’s walloping me. I can’t stay awake and the nausea is terrible. I am losing weight now though. […]"
– AppropriateStrike1
Another account also had a hard start, though with a clearer end point: a couple of bad days, then an improvement, after a month with no symptoms at all.
"I had some pretty debilitating nausea during the first two days on 2.5 (after experiencing no symptoms or benefits on .8). Days 3-6 have been noticeably better. […]"
– FranklyFrozenFries
And then there are those for whom the step passes with little comment, apart from a more noticeable change in appetite.
"I moved to 2.5 last week and I’ve got the same slight side effects as on .8 - occasional indigestion. No other side effects. The one thing I have noticed is that while .8 shut down a lot of the food noise, this dose has completely shut it down, plus the feeling of satiety is much clearer. […]"
– expatinpa
When the Main Event Is Tiredness
Tiredness comes up again and again in threads about the 2.5 mg step, usually as a practical problem rather than an abstract one.
"First week on 2.5mg and I'm dying. By 4 or 5 pm I can barely stay awake. I tried to go to boxing and it was like I was in slow motion and then I couldn't barely lift my arms after that. […]"
– slapping_rabbits
Replies to that post turned mostly on time, and one person described setting themselves a deadline and waiting it out.
"I was in your same shoes and gave myswlf the full 2.5 weeks to adjust OR I was going off/back down. Miraculously I felt better right at 2.5 weeks in."
– ElegantCommercial994
Not everyone stays long enough to find out. Another post, written on the same strength, ended with a decision.
"I’m having headaches and extreme moodiness on 2.5. I just feel bad. Plus I am exhausted. Like wanting to sleep all day. I think I’d rather have extra weight than deal with this. Ugh. I’m stopping it."
– naughtygirlatnite
Under that thread sits a longer account from someone who did stay, describing a stretch of difficulty that outlasted the first fortnight before it eased.
"I had 3 and 1/2 weeks of moodiness and mild fatigue but it finally went away. I'm on my second month of 2.5 since it's doing well for me but yeah, I totally understand the urge to go off. […]"
– HalleFreakinLujah
Higher Up the Ladder
Beyond 2.5 mg the accounts become more varied still, and first doses of 5.5 mg and above are often described with the same surprise people used for the earlier steps.
"I felt the effect of 0.8 immediately then it tapered. The 2.5 was stronger and I didn't feel that the effect diminished much over time. Just took my first 5.5 last night and omg. Can't imagine putting anything in my mouth. I'm not nauseous or uncomfortable. This is profound. […]"
– inh-exh
For others the higher strengths bring little to report at all, and the question becomes whether to stay where they are.
"I am on 9mg, everything is completely fine on this dose. Not sure if I’ll stay on it another month or look to go up. […]"
– ss0826
Then there are accounts in which each step seemed to add to the last, with the short-lived nausea of one increase giving way to something more persistent at the next.
"i’ve been on foundayo for around 3 months now i started with 0.8mg and had no side effects, when i increased my dose to 2.5 i had bad nausea for the first and second day, and then i just started 5.5mg in august 1 and the nausea has been unbearable. […]"
– noory343
What these people share is less the experience than the question that follows it: whether the step is doing what they were waiting for.
Waiting for a Step That Does Something
Not all of the anticipation is about side effects. Many posts describe the starter strengths as quiet and the next increase as the one people are waiting on.
"I’m three weeks in at the 0.8 dose and noticing my appetite coming back. Having to track calories to keep from going over. No weight loss to speak of yet. I have about 40 to lose. Looking forward to bumping up."
– GinaHannah1
The same waiting appears in posts from people who moved over from injections and are hoping the next strength will make up the difference.
"Moved to 0.8mg of Foundayo 1 month ago and about to take my first 2.5mg tablet today. […] I don’t feel like the lower dose suppressed my appetite much at all but I have noticed a lot of bloating and burping going on."
– FlossieApricot
The step up does not always deliver what the waiting promised, as one person who reached 5.5 mg after two months of lower doses put it.
"I’m at the end of month 3 . Went up to the 5.5 mg last month . I’m done . Lost a total of 9 pounds and it is way not worth it . […]"
– Hopeful-River-7899
Staying Put, or Going Back
A smaller group describes choosing not to climb at all, for reasons that have little to do with side effects.
"I think a lot of this depends on your weight loss goals too. I'm comfortable losing 1lb every two weeks, so I don't need a higher dose with more potential side effects. […]"
– pinback77
Cost sits underneath many of these decisions, and in the prices people post, each strength costs more than the last. This account quotes US dollars.
"I am not looking to continue losing. I need a maintenance dose. Also, cost is a factor. The .8 is $149/mo and the next dose up is $199. I can’t really afford to go much higher."
– kjb76
For one person who had come to Foundayo directly from the highest dose of an injection, the question was larger still: whether to climb a ladder of unfamiliar steps or return to what they knew.
"No I'm wondering if I go up the doses or switch back as the transition period is currently very difficult. […]"
– ILoveaSunflower
What Does Medino's Pharmacist Think?
"What stands out is how little any one account predicts the next. The same step can pass almost unnoticed for one person and feel like a wall for another, and people differ in what they are hoping the next strength will do. These threads are best read as a record of how varied the experience is, which is probably why people compare notes so closely."
– Alessandro Grenci, Pharmacist at Medino
One Ladder, Many Experiences
Read together, the threads do not describe a single dose increase. They describe a series of separate moments: a step that was dreaded and passed, a step that was tolerated and then regretted, and a step that people are still waiting to take.
What they have in common is attention. Each new strength becomes a reason to watch the days that follow closely, and to compare them with what a stranger online has written.
