Foundayo and Libido: How It Affects Sex Drive
Foundayo (orforglipron) is a once-daily tablet authorised in the UK for weight management, and it is new enough that the online conversation about its effect on sex drive is still small. A handful of people have asked the question outright, and the answers are not uniform: two people describe a dip, one notices nothing, and one reports the opposite.
These are personal accounts from public forums. They cannot show how common any of this is, or whether the tablet has anything to do with it, and several of the writers say as much themselves.
Because Foundayo threads on the subject are thin, this piece also draws on people taking Mounjaro, Zepbound, other GLP-1 medicines and retatrutide. Those accounts are labelled as such wherever they appear, and they describe different medicines, not Foundayo.
When Desire Goes Quiet
The most direct account comes from a thread that put the question to other men. Its author described a drift in desire over a decade or so, which he thought unremarkable, and then something sharper after starting Foundayo.
"So, I’m a 38 year old guy, and I would say my libido has gradually been going down since my twenties, which is normal enough. […] However, when I take Foundayo, I noticed that it REALLY goes down. I’m single, and I normally masturbate a few times a week. On Foundayo though, it just feels like my dck is totally numb, and I have to force myself to come. Like, it takes a while."*
– Flat-Apartment7859
He asked whether anyone else recognised it, and added that it was hard to know how much was placebo, a doubt that hangs over almost everything in this article. A reply from someone using Foundayo for maintenance, after losing weight on Zepbound, followed the timing more closely.
"I've noticed it suppressing my libido. I'm using Foundayo for maintenance. […] After titrating up to the 2.5, my undesirable side effects (Sulphur burps + vomiting) returned and I temporarily discontinued the Foundayo. That's when I noticed my libido returning to pre-Foundayo levels, about 4 days after stopping."
– Wild-Lavishness-9139
In that second account the change is tied to days on and off the tablet, with desire described as returning within about four days of a pause. It is a single person's observation, but it is the kind of detail that makes the pattern feel less abstract. Not everyone in the thread recognised it, however.
Not Everyone Notices a Change
The shortest reply in the same thread was also a flat denial.
"I've not noticed any impact on my sex drive"
– jamesdew84
At the other end of the spectrum is someone who moved to Foundayo from a weekly injection and found the shift went the opposite way. Their account of the first weeks mixes appetite, mood and desire, with libido mentioned as one improvement among several.
"Hey, I just switched from 12.5mg Zeppbound to 9mg of Foundayo. […] It’s so much more consistent and regular, I don’t feel depressed/disgusted by food anymore and my libido has gone way up."
– Puddinbunny
That post drew a reply from a person still on tirzepatide, the active ingredient in Mounjaro and Zepbound, who hoped for a similar change.
"I’m hoping my libido goes up too! It has taken quite a hit on Tirzepatide."
– IncidentGreat2380
It is a reminder that people compare notes across medicines, even when the evidence for doing so is a single sentence from a stranger. The rest of this piece follows that habit, starting with people on Mounjaro.
Elsewhere: The First Weeks on Mounjaro
In a UK thread about Mounjaro, a nine-week-old post set the tone with a flat description and a question about whether it was shared.
"I started MJ about 9 weeks ago and have noticed that things in that department have slowed right down. Like, zero urge. Nothing. Obviously MJ affects everyone differently but wondering if anyone can relate?"
– NoProcedure5840
The replies were mixed, and one came from a commenter who recognised the slump but said it had not lasted.
"I had this for the first few weeks. Been quite the opposite since!"
– stek2022
The thread soon turned to why it might happen at all, a question taken up further below.
Up, Down and Unchanged
A separate Mounjaro thread on the same subject drew answers that ran in every direction. Early on, one person reported a rise in desire and could not say whether to credit the medicine or the new routine of exercise and healthier eating that came with it.
"Currently on week 5, 1st week of 5mg. Strangely, it has had an increase on my libido. Not sure if it is the medication or exercise along with the healthy eating."
– SomeGuyUK50
For someone else the rise had a hormonal flavour, and a body that felt lighter seemed to help.
"I'd say my libido has been increased! I think something hormonal was going on for me and mj has balanced it? Plus feeling lighter and better about my body helps! Feel more like the woman I was 5 years ago!"
– lady_lazurus
Others described the opposite. One person said desire had fallen sharply, though not to nothing, and noted that even the one trigger that used to be reliable had stopped working.
"my libido actually has dropped quite significantly but it’s still there, though not even my menstrual cycle kicks it off these days, which used to be pretty much guaranteed"
– Ijustwantacuppa
A man in his thirties separated two things that are easy to run together: how much he wanted sex and whether it ended the way it used to.
"Weirdly, my libido is probably the same but my ability to ‘finish’ has decreased. A few times on 5mg+ it just doesn’t happen for me despite nothing changing in the practice of it all."
– LetHeathensRip
Away from the Mounjaro threads, a similar surprise appeared in a list of unexpected effects of a GLP-1 medicine, from someone who had expected the reverse and did not name which one they were taking.
"I think I’ve noticed my sex drive is up. To me this is weird because I thought glp1’s tended to make sex drive less? I’m on the .5 dose and barely my 2nd month in."
– BeautifulLife30
Whether any of this belongs to the medicine, the weight loss, the mood or something else entirely is what people keep trying to untangle.
The Theories People Reach For
The explanations offered are plentiful and unproven. One Mounjaro user, replying to the nine-week post, offered a theory about the body trimming what it considers non-essential once it is eating less.
"There's a theory that as you reduce your calorie intake your body reduces the need for non-essential activities, like reproduction, etc. in order to maintain your weight set-point."
– newton_uk
A different line of thinking connects desire to pleasure in general. In a thread comparing semaglutide and tirzepatide for emotional flatness, one person drew a direct line from losing interest in food to losing interest in sex.
"I've experienced this but with a complete loss in sex drive, I stopped caring about food and that same effect caused wanting sex to go along with it. I just have a hard time caring now"
– Lunnalai
Both ideas are the writers' own readings of their experience, and they point to different places: one to the body's priorities, the other to what pleasure means. Retatrutide threads put the question even more bluntly.
Retatrutide Accounts
Retatrutide is still an investigational medicine, and the accounts here come from a trial participant and from a thread about switching away from it. The trial participant gave the most detailed description in the whole set, with desire and erections both affected and, by his own account, only partly recovered.
"The worst for me was the impact on my sex drive. Prior to starting the trial I had a very high libido. Once on the medication in addition to reduced/nonexistent libido, I also experience erectile dysfunction. I had a hard time getting hard, staying hard, and was never as hard as before the medicine. Happy to say ED is no longer an issue but my libido is not back fully yet."
– atlhart
For another person, a switch away from retatrutide marked the turning point.
"I took Reta for 6 months, and suffered from a diminished sex drive, and other negative mental health side effects. I switched to Tirzepatide 6 weeks ago, and am feeling like myself again. Libido and joy are back! This is just one persons personal experience!"
– Stempath
Their experience did not match that of everyone in the thread, because one poster described a very different result.
"My sex drive is thru the roof. Not sure if it’s Reta or what"
– 10aciousLei
The thread had begun with a question about libido but soon widened. The person who asked said the loss reached beyond sex.
"It kills my drive all together. Not just sex. Even working out and doing things I enjoy."
– Fit-healthty-Couple
A reply tied that to eating less overall, and suggested the body might be giving some functions a lower priority when calories are limited.
"Something to consider is if you are in a caloric deficit, your body is going to prioritize certain physiological functions. Could be horny time gets put on the back burner."
– dingodonkey03
What Does Medino's Pharmacist Think?
"What stands out is how mixed these accounts are: some people describe a dip, some notice nothing and a few describe the opposite. Sex drive is shaped by a lot at once, including mood, energy, sleep and how someone feels in their body, so it is hard to say what any one person is responding to."
– Alessandro Grenci, Pharmacist at Medino
One Question, Many Answers
Read together, the accounts do not agree on a direction. Two Foundayo users describe a quieter libido, one describes a livelier one and one noticed no change. The wider threads add the same spread, with people unsure whether to credit the medicine, the weight loss, their mood or the calendar.
For now the Foundayo conversation on this subject is short, and the people having it are still working out what they are noticing.
