Foundayo and Menopause: Weight-Loss Experiences
For some women, weight arrives with the menopause transition in a way that feels out of step with everything else they are doing. Meals do not change, the exercise carries on, and the scale drifts upward anyway. Some of them are now writing about trying Foundayo (orforglipron), the once-daily weight-loss tablet, and what happened next.
What follows is drawn from personal accounts in public forum threads, not from research, and it cannot say how common any experience is or what lies behind it for any one person. Most voices come from Foundayo threads; a couple describe other medicines they used before switching.
The accounts run from the first frustration, through very different early results, to the changes people notice away from the scale, the other treatments running alongside, and the practical reasons some arrived at a tablet at all.
The Weight That Arrived With the Change
The stories tend to begin in the same place: a long list of things already tried. One person in perimenopause, starting a first GLP-1 medicine on the day they posted, set out the list in a single breath.
"It’s been so frustrating not to lose weight from the perimenopause weight gain. Nothing has worked. I workout, eat well, and even worked with a nutritionist who was great."
– diyfilms
The effort in these accounts rarely drops, which is part of what makes the picture so confusing. A woman of 50 described years of being active and careful with food, and a weight that went one way regardless.
"I was always super active and ate very clean, but perimenopause made sure I only gained weight every single day, even in a calorie deficit."
– Opposite-Hall-5128
Others describe the change as bodily as much as numerical. Across roughly a year and a half, a 53-year-old woman felt her shape move so far that she no longer recognised the person in the mirror.
"I have gained 40lbs since Dec 2024 due to Peri […] the fact that my body changed so much that I don't recognize myself."
– Pretty_Confidence377
Having reached the point of trying something new, people then discover that the early weeks look very different from one person to the next.
Different Speeds
Some accounts read like a sudden release. Ten weeks in, someone aged 51 had lost 13lb and put the contrast with their years of effort plainly.
"I am on week 10 and have lost 13lb, which I am really happy with. […] Foundayo at 0.8mg has been like a fountain of youth for me: I am still doing all the right things but now they are actually working!"
– Consistent-Slice-840
The pace is not always so steady, even for the people who do lose. In a thread started by someone who was postmenopausal, one reply described a quick drop in the opening week followed by a steadier rate of a pound or two a week.
"I dropped like 6 LB in the first week but then leveled out to 1-2 LB per week."
– shehulud
For others the first month brings no loss at all, but a different kind of change. A 62-year-old wrote about a first month with no loss at all, but one in which the weight at least stopped climbing.
"The first month (.8) I didn’t lose any weight but finally stopped gaining, food noise went away for the first couple of weeks but started to return."
– GinaHannah1
And then there are the people for whom neither shows up. Posting under a stranger's success story, one reader moved up a dose and found the same blank.
"I started on the 08 didn’t phase me. Then went to 2.5 on the first week of July. Nothing!"
– MobileBlackberry3151
Whatever the scale did, many people said the more striking changes were happening somewhere else entirely.
Beyond the Scale
Joints came up repeatedly. One woman who was already on hormone treatment and had still been dealing with aches wrote about waking on the third day to find the stiffness had gone.
"Day3 was the turning point though, despite the nausea, I woke up and realized - my legs arent stiff? All my muscle and joint pain was GONE."
– crowber
Swelling was another recurring theme. Someone who put on 20 to 25 pounds in the years after the menopause said they had worn strong compression socks every day, and described what they noticed within days of starting the lowest dose.
"In about 2-3 days on .8 I noticed my ankles were no longer swollen. […] The swelling is just . . . .gone. I hope it never comes back."
– UnitedAside4734
The same word turned up around the middle. Replying in a thread where another person had just posted their own early results, a reader said the first change they saw was in the abdomen rather than the weight.
"That was the first thing I noticed when I started! My stomach flattened. All that perimenopausal swelling was down."
– Admarie25
Sleep, too, made an appearance in an account from someone only a week into the lowest dose, where the benefit was not about size at all.
"I sleep really well (I take the pill before bed), and this is a big deal because my sleep in perimenopause has been consistently poor."
– Fair-Organization-61
All of these changes happened alongside a great deal else, and that is where several people grew more careful about what they were crediting to what.
A Lot Going On at Once
Hormone treatment appears in several of these stories, and it sits next to Foundayo rather than being replaced by it. In a thread about eighteen days on the lowest dose, a reader who had just taken their first tablet looked back at restarting HRT and what they had hoped it would do.
"I started HRT a couple of months ago after a short break after the first 3 weeks of trying it. I was hopeful for less food noise - but that wasn't going well today."
– Due-Rub1448
Dose changes brought their own surprises. After moving up to 5.5mg, one person reported feeling more tired and mentioned a second change in the same breath.
"I am DEFINITELY more tired on the 5.5 and, I also noticed, I had some hot flashes in the morning."
– 3Sides2EvryStory
For some, the worries came before the first dose, and they were practical ones about how to eat well and keep hold of the muscle they had built.
"I just know as a stressed out perimenopausal woman, fixing my diet is going to be the hardest part of a weight loss journey. I am also worried about losing muscle."
– TyronesMom
Beneath all of this is the question of how a person ended up here, and for many the answer involved another medicine first.
From Injections to a Tablet
Several people describing menopause weight had already used injections, and the tablet appears in their stories as a next step rather than a first one. One had lost 26lb that way and was planning what came after.
"I dropped 26 lbs of menopause weight over 5 months on 2.5 mg weekly Zepbound. […] Very hopeful the pill will work for my maintenance since lowest shot if 2.5 mg had me still losing."
– Irasshaimase21
Cost sits behind several of these moves. In a UK thread, a woman in her fifties explained why she stopped her injection and why she decided to try the tablet instead.
"Unfortunately, I had to stop in May when the cost of continuing on 15mg became too difficult to justify. Since then, I’ve regained roughly 7lb. […] We’re realistic that the weight loss may not be as quick as it was with MJ, but that’s okay."
– Acceptable_Cow6658
Not everyone arrived with a plan or a budget. For one person, just starting their second week, the move came out of a sense that something had to change.
"Perimenopause has been kicking my ass. The weight just piled on no matter what and I have been physically miserable. I’m hopeful this will be the thing that finally helps."
– Responsible-Focus197
What Does Medino's Pharmacist Think?
"What stands out in these accounts is how often the menopause transition and weight sit together in people's stories, and how different the rest of each story is. Some people describe changes in the first days, others see very little, and each is describing their own medicines, dose and circumstances, so what the accounts show is a range rather than a single pattern."
– Alessandro Grenci, Pharmacist at Medino
No Single Story
Read together, these accounts do not describe one experience of Foundayo in the menopause years. They describe a handful of different stories that share a starting point: a body that stopped answering to the usual effort, and a hope that something would shift.
What they have in common is attention. People note the dose, the week, the joint that stopped aching and the tablet that did nothing, and they compare notes with strangers who are doing exactly the same.
