How to use Wegovy 7.2 mg safely
Using Wegovy 7.2 mg safely is about more than following an injection routine. Because this is the highest approved dose of semaglutide, it requires greater attention to tolerability, hydration, and early warning signs that the dose may be too much for an individual patient.
Most people who reach 7.2 mg have already spent months on lower doses, which helps reduce risk. Even so, the step up can feel different.
Timing and consistency
Wegovy 7.2 mg is taken once weekly, on the same day each week. Consistency matters, as irregular dosing can worsen side effects and reduce effectiveness.
Because the current dose requires three injections on the same day, it is important to plan ahead and ensure you have enough pens and needles available before your dosing day.
Correct administration at the current dose
Until a single-dose pen becomes available, the full 7.2 mg dose is delivered through three 2.4 mg injections taken one after another on the same day.
Injections can be given in the same body area, such as the abdomen or thigh, but should be spaced at least 5 cm apart and never injected into skin that is sore, bruised, or inflamed. Each injection must be given with a new needle.
What tends to change at higher doses
At 7.2 mg, side effects may feel more pronounced, particularly in the first few weeks after the increase. Digestive symptoms are the most common and may include nausea, bloating, reflux, diarrhoea, or constipation.
Another effect seen more often at this dose is dysaesthesia, which refers to unusual or unpleasant skin sensations such as burning, tingling, or heightened sensitivity. These symptoms are dose-related and should prompt early discussion rather than being pushed through.
As Alessandro Grenci, Superintendent Pharmacist at medino, notes:
"When patients feel something new or uncomfortable at a higher dose, the safest response is to pause and review rather than assume it will settle on its own."
Hydration and daily habits
Reduced appetite can make it easy to drink less without noticing. At higher doses, dehydration becomes one of the most common contributors to fatigue, dizziness, and worsening side effects.
Small, regular sips of fluid throughout the day are often better tolerated than large volumes at once. If nausea or vomiting prevents you from keeping fluids down, medical advice should be sought promptly.
When to step back and seek advice
Not all side effects are expected or acceptable. Persistent vomiting, ongoing diarrhoea, severe abdominal pain, unusual skin sensations that do not improve, or signs of dehydration all warrant clinical review.
If symptoms are severe, sudden, or accompanied by swelling, breathing difficulty, or chest pain, urgent medical assessment is required.
Looking ahead
A single-dose 7.2 mg injection device is planned for launch in summer 2026, subject to regulatory approval. This is expected to simplify administration but will not change the underlying safety principles.
Higher doses are not about speed. They are about careful adjustment, honest symptom reporting, and choosing the dose that delivers benefit without unnecessary risk.
Used thoughtfully, Wegovy remains most effective when dosing decisions are guided by safety rather than pressure to escalate.
