# Nothing Happening on 2.5mg: Why Some Users Don’t Feel Mounjaro Right Away
Starting Mounjaro at the 2.5mg dose can be an emotionally complex experience. Some people feel dramatic changes in appetite, cravings or mental "quiet" within days, while others feel almost nothing and begin to worry that the medication is not working for them. The contrast between expectations and reality can create doubt, especially when weight loss does not begin immediately or when the strong effects felt in week one taper off.
The earliest weeks on a GLP-1 medication often involve uncertainty. People frequently describe wondering whether they injected correctly, whether the dose is too small, or whether their body simply "isn’t responding". For many, this becomes stressful—especially if the motivation to start treatment was driven by long-standing struggles with appetite regulation or weight management.
It is also common for people to compare their experience with others who report rapid changes on day one. This can lead to the mistaken impression that a lack of immediate appetite suppression means treatment failure. In reality, the starter dose is designed to be gentle and is not meant to deliver full therapeutic effects.
This article explores these early dose experiences, why some people do not feel much at 2.5mg, and how others have navigated the weeks before higher doses begin.
Why Some People Don’t Feel Much on 2.5mg
The most consistent theme across user experiences is that 2.5mg is widely recognised as a starter dose—a way to introduce the medication slowly rather than deliver full therapeutic effect. Many people note that this initial dose simply isn’t strong enough for noticeable appetite suppression.
As one user explained:
"Mounjaro is a drug that takes time to build up in your system, and 2.5mg really isn't meant to do much of anything other than get your body used to it." -miguelitaraton
Another person put it more plainly:
"2.5mg is essentially to get your body used to the drug before stepping up to the first effective dose (5mg). For some people they have great success with 2.5mg, but it's not expected." -anonymous
There are also users who felt nothing for the first one or two doses and then suddenly noticed the medication "kick in" later. This variability can make the waiting period confusing. For some, the first week brings a placebo-like rush that fades quickly, creating disappointment when appetite returns.
One user captured this trajectory clearly:
"The first week I could feel my medicine work at a 2.5 dosage but it only seemed to work for about five days… my second injection felt like nothing." -Quiet-City-7529
These patterns highlight that early experiences—positive or absent—often do not predict longer-term outcomes.
What People Actually Experience at This Dose
Across online forums, several people described a complete lack of appetite change, food-noise reduction or weight loss in the first weeks. Others found their hunger suppression faded quickly after a strong start. For many, this caused frustration or self-doubt.
One user shared the concern:
"If I'm feeling nothing now… what's affecting my mind is the possibility that I won't feel anything the next 2 weeks either." -yoshibinks
Others noted that even with no suppression, small lifestyle changes kept them going:
"I have been keeping my eating under control although it is very hard but I cut on carbs so much which helped." -Famous-Jack
Some emphasised the emotional weight of feeling the early benefits slip away:
"I know I'm capable of it, but this psychological hold my weight, food and my lifestyle has on me feels paralysing." -yoshibinks
Others maintained progress but worried about inconsistency:
"It only seemed to work for about five days… do I need to be on a higher dose right away?" -Quiet-City-7529
These accounts underline that feeling "nothing" on 2.5mg is extremely common, even among people who later respond strongly to higher doses.
Hitting Plateaus or Losing the Effect
Many people described a familiar pattern: early appetite suppression, followed by a sudden return of hunger or food noise later in the month. This led some to assume the medication had "stopped working", even though their dose had not yet been increased.
One user’s experience reflects this shift:
"My first month on 2.5 was amazing… now I’m barely feeling any benefits at all. Haven’t lost weight in three weeks." -Few-Cat-6352
Another person described the feelings that return when the initial appetite quieting fades:
"I'm quickly thinking about my next meal… I don't feel full, I'm thinking about food, and I can eat way more than I could last week." -yoshibinks
Some users highlighted that this is expected physiology, not treatment failure:
"It’s common to feel exactly what you’re feeling during the first month, a great start that peters out… each successive dose will actually build up more and more drug in your system." -Jindaya
A number of people described magnified hunger during certain weeks of their cycle or during periods of stress, which can temporarily mask appetite suppression.
Plateaus of one to two weeks were frequently described as normal, especially early on.
When Dose Increases Make a Difference
A key pattern across experiences is that many who felt nothing at 2.5mg began feeling significant effects at 5mg or later. Some did not feel meaningful appetite reduction until 7.5mg or even 10mg.
For example:
"2.5mg had no effect on me but 5mg certainly did. I'm now 50 lb down from April." -EducationalBrunch528
Another user described dramatic change once the dose increased:
"I injected my first 5mg dose yesterday and woke up today feeling like I’d had a Christmas dinner… it's managed to stop my hunger all day." -Material-Bid-4195
Others stressed patience:
"Some folks don't feel anything significant until 7.5mg… keep going and go up in dose after your 4th shot." -RlyVSS
And some reminded others that effects vary widely:
"Some people do well at 2.5mg indefinitely. Others need to go up to the higher doses to get a response." -Jindaya
Together, these accounts reinforce that early non-response does not predict long-term success or failure.
Pharmacist’s Comment
According to Alessandro Grenci, Superintendent Pharmacist at Medino, a lack of strong effects at 2.5mg is entirely expected and not usually a cause for concern.
"The 2.5mg dose is intentionally gentle. It prepares the body for treatment rather than delivering full therapeutic appetite suppression, so many people feel very little in the first few weeks." -Alessandro Grenci, Superintendent Pharmacist at Medino
"GLP-1 medicines work by gradually building up in the system. For some, this means the noticeable benefits appear only after moving to 5mg or later doses."
"If hunger or cravings return after an initially strong response, it does not mean the medicine has stopped working. It may simply reflect the natural adjustment phase before the dose is increased."
Final Thoughts
Feeling "nothing" on 2.5mg is one of the most commonly shared early experiences with Mounjaro. The starter dose is designed to be gentle, and many people only notice real appetite suppression, reduced food noise or steady weight change once they move to higher doses. Plateaus, fluctuations and periods of doubt are part of the process, not signs of failure.
Users consistently encourage patience: trust the titration schedule, communicate openly with your prescribing clinician, and focus on gradual, sustainable habits while waiting for the medication to build. As one user put it simply, this isn’t a race.
Whether you felt dramatic effects in week one or nothing at all, many people eventually find that Mounjaro begins working more reliably as their dose increases. The early weeks may feel uncertain, but they do not determine your long-term journey.
