Wegovy and Libido: How the Medication Affects Sex Drive
When people talk about Wegovy (semaglutide), the focus is usually on weight loss, appetite changes, or side effects like nausea and constipation. But tucked away in online forums, another conversation has been unfolding-about how the drug affects libido and sexual health.
Some report their sex drive has disappeared altogether. Others say they feel hornier than they’ve been in years. And plenty fall somewhere in between, noticing no real change.
This article brings together real user experiences to show how Wegovy can reshape intimate life-for better, worse, or not at all.
"My Sex Drive Has Dropped"
For many users, one of the most surprising effects of Wegovy is a sharp drop in sexual desire.
"Yes, my already low libido went down to absolute zero on Wegovy. Zepbound is slightly better in that regard." -TropicalBlueWater
"5 months in. Zero sexual interest. Went out the window about month 3." -NewOpportunity467
"I know something is wrong, but… ever since I started Wegovy I have had zero libido. It was low before, but now just non-existent." -Beescroft
For these users, sex feels less appealing, orgasms are harder to reach, and physical intimacy becomes more of a chore than a pleasure. Some link this to fatigue, nausea, or hormonal changes brought on by rapid weight loss. Others simply don’t understand why their sex drive has vanished.
The emotional fallout can be significant. Partners may feel rejected, while patients themselves struggle with guilt or frustration.
"I’m Hornier Than Ever"
On the flip side, some users report the opposite: a dramatic surge in libido.
"Bruh, even the crack of dawn isn't safe around me right now." -GrumpyDawgVS
"Any women experiencing huge libido increases in ovulation week due to Wegovy?… I felt like a sex-obsessed deviant." -JellyBeanTears78
"I’m a 33f, and my libido has been through the roof… that might also have to do with my increased confidence/self esteem with having lost weight." -Bears_abbey1104
For these people, weight loss and improved self-image may play a big role. Feeling healthier, lighter, or more confident in one’s body often translates into greater desire. Hormonal shifts may also contribute, particularly for women around ovulation or men experiencing testosterone rebounds after weight loss.
No Change at All
A large portion of users notice no significant change at all in their sex drive while on Wegovy.
"No impact for me. 46 year old female." -jessbyrne727
"No impact on libido." -rowan1827
"No change for me on the libido side of things. I’m definitely less depressed than I was off the meds." -gutsybunny
For this group, libido is more likely influenced by age, mental health, relationship dynamics, or other medical conditions rather than by semaglutide itself.
Why Does This Happen?
So why are experiences so different?
Biological factors:
- Hormonal shifts: Rapid weight loss can temporarily reduce sex hormones like estrogen or testosterone. For men, low testosterone is sometimes reported.
- Calorie restriction: Eating less can reduce available energy and blunt sexual desire.
- Dopamine/reward pathways: Wegovy alters how the brain responds to cravings, and this may spill over into sexual desire-similar to how some users lose interest in alcohol.
Psychological factors:
- Confidence boost: Weight loss often improves self-image and can unlock a stronger sex drive.
- Side effects: Fatigue, nausea, and constipation can make intimacy less appealing.
- Stress and mood: Anxiety about weight plateaus, health, or relationships may dampen libido.
This mix of biology and psychology helps explain why Wegovy’s impact on sex drive can go in opposite directions for different people.
Male vs Female Experiences
Gender appears to shape how libido shifts on Wegovy.
Men often report erectile difficulties, lower testosterone, or performance issues:
"53 y/o male here… noticed the past three times I’ve had sex have resulted in rocket failures. Just got a lab order to check my testosterone levels." -PollutionMuted9763
Women sometimes describe total loss of desire, dryness, or discomfort:
"Female on 2.4mg Wegovy – libido gone to ZERO… I have tried Addyi, it just made me dizzy." -Beescroft
"I went into surgical menopause… but it wasn’t until I started sema that my libido really decreased and orgasms feel strangely uncomfortable." -No-Country6348
Others-both men and women-find their sex drive soaring, suggesting that individual hormonal makeup, age, and life stage all matter.
Coping Strategies and Community Tips
Faced with changes in libido, many users share strategies that have helped them adapt:
"Hit the gym, start lifting weights to increase testosterone naturally." -CVSaporito
"Have them run a hormone panel… you can ask your provider if they’re good with you trying to add Ashwagandha." -TJeter19
"Please do some reading about spontaneous vs reactive desire – it may prove interesting and helpful." -[deleted]
Common community tips include:
- Exercise: especially strength training, to support testosterone.
- Supplements: maca, ashwagandha, or vitamin D are often mentioned.
- Medications: some experiment with Addyi, Wellbutrin, TRT (testosterone replacement therapy), or PT-141.
- Communication: being open with partners about changes helps manage expectations.
Relationship Challenges
Changes in libido inevitably affect relationships. For some, the impact is subtle; for others, it strains intimacy and communication.
"Been on Wegovy for a year and it seems like it’s now gone [libido]! To be fair I’m going through menopause… but wondering if anyone has had anything similar?" -Dogmama2712
"Help. I’ve lost my libido… it’s affecting my marriage. Even if I take sildenafil or tadalafil I will get an erection, but it won’t last." -SessionRemarkable723
"Since then I’ve settled into the changes and my libido has dropped again. I suspect it’s all tied up in other things being less important like alcohol and food." -figuring_ItOut12
Couples often navigate this by seeking medical advice, adjusting expectations, or focusing on intimacy outside of sex. For some, the hope is that as the body adapts to Wegovy, libido will balance out.
When to Seek Professional Help
If changes in sex drive are persistent, distressing, or damaging relationships, it’s worth seeking medical guidance. A GP or endocrinologist can check hormone levels, review other medications, and discuss options ranging from supplements to prescription treatments.
Pharmacist Alessandro Grenci offers this perspective:
"Libido changes on Wegovy are not uncommon. For some, they pass after a few months as the body stabilises; for others, they reflect hormonal or psychological shifts. If low libido is causing distress, it’s important to rule out other causes and explore treatment options. Equally, if libido has increased, that can be a positive change-but it’s still worth discussing if it becomes disruptive."
Conclusion: An Intimate Side of Wegovy
Wegovy is widely known for its ability to reduce appetite and drive weight loss. But for many users, it also affects an intimate and often overlooked part of life: libido.
For some, sex drive plummets, creating frustration and relationship strain. For others, it skyrockets, adding energy and frequency to their intimate lives. And for a large group, nothing changes at all.
The key takeaway is that libido changes are highly individual-and nothing to be ashamed of. By tracking symptoms, being open with partners, and seeking professional guidance when needed, users can navigate this side effect without losing sight of the bigger picture: improved health and wellbeing.
