Wegovy Not Working Anymore: What to Do
For many people, starting Wegovy brings a sense of hope. The early weeks often come with clear appetite changes, easier portion control, and the feeling that something is finally shifting. But for others, that early progress slows down, stalls, or never appears at all. And for a noticeable minority, even the highest dose simply doesn’t bring the appetite suppression or weight change they expected.
The emotional impact of this can be enormous. People often describe feeling confused, frustrated, or even ashamed when they see others having rapid success while they are stuck. Many begin to wonder if they are "doing something wrong", or whether their body simply doesn’t respond to the medication.
This article brings those experiences together. It looks at the patterns people describe when Wegovy stops working or never really takes hold, the factors that may influence this, and what others have done next.
When Wegovy Never Fully Kicks In
A recurring theme is the experience of never feeling any meaningful appetite suppression, even after months on treatment. People describe doing everything they can - exercising, tracking calories, cooking at home - yet feeling almost no physiological change from the medication itself.
"I’m on week 5 no weightloss , no side effects." -herewegoo_
Some reach the maximum dose without ever having the shift others talk about.
"Wegovy did not for me at all lost Zero weight and yes I was on the highest dose." -MeanLie4152
Others report only very small changes over long periods, leaving them unsure whether the medication is helping in any meaningful way.
"Neither W nor Z has suppressed appetite for me. No side effects and minimal loss of 15 pounds over 7 months." -EitherClick1393
For these users, the emotional impact is significant. Many feel discouraged, especially when they see people losing quickly on the same medication. But as their stories show, a lack of response is more common than people realise, and it often isn’t due to poor effort or lack of discipline.
Different bodies respond differently - and for some, Wegovy simply isn’t the right fit.
When Results Slow Down or Completely Stall
It’s also common for people to start strong, only to hit a plateau that lasts months. Some describe losing early weight on the lower doses, then stalling completely as they reach 1.0 mg or 2.4 mg.
"I stopped losing on Wegovy… it did nothing for me the last two, almost three months." -vintagefan2
Others find that appetite slowly returns and the early suppression fades.
"I’ve been at the highest dose for 3 months now and have been going up and down between the same 2lbs the entire time." -StayAtHomies
A few describe weight loss stopping altogether despite consistent calorie control and regular exercise.
"I have plateaued on highest dose of wegovy 2.4. I have not lost any weight since being on 1.00." -Swimming_Arm207
For many, this shift feels sudden and inexplicable - as though the medication has simply "switched off". In some cases, increasing activity or adjusting food choices helps, but for others, no amount of effort changes the outcome. This pattern can be discouraging, but it is clearly shared by many.
Switching to Another Medication
One of the strongest themes is the number of people who ultimately find success only after switching to a different GLP-1 medication. For many, Zepbound or Mounjaro offers noticeably stronger appetite suppression or more steady weight change.
"I stopped losing on Wegovy… so my doctor just switched me to Zepbound." -vintagefan2
This experience is echoed repeatedly:
"Wegovy didn't work for me. I was on it for a year… Zepbound, on the other hand, is amazing." -Hairy-Departure-5451
And again:
"About 10–15% of people are unresponsive to Wegovy… Maybe consider Mounjaro/Zepbound?" -InnerButterflyy
Many people describe losing little to no weight on Wegovy, then beginning to lose steadily once they switch. Others note that they feel better mentally or physically on the alternative medications, even when the dose is still low. It reinforces the idea that these medications are not interchangeable - and that individual biology plays a major role in how effective each one will be.
Exploring Other Factors
Some people find that dose, timing, or food patterns influence their response. A few discover practical issues - from underestimating calories to inconsistent routines - but others note that they were doing everything "correctly" and still not seeing results.
"I tracked food. I increased protein. I exercised. Almost DONE." -EitherClick1393
In rare cases, mental health, hormone changes, or underlying conditions may be relevant. A few users share experiences where emotional eating patterns, anxiety, or medical issues made weight loss more complicated.
"These drugs didn’t work for my mom… it is her thoughts that tell her she wants to eat." -cMeeber
Others mention thyroid issues, perimenopause, or metabolic challenges as factors worth exploring. While not always the cause, they are worth discussing with a clinician when progress is unusually slow or absent.
Pharmacist’s Comment
According to Alessandro Grenci, Superintendent Pharmacist at Medino, it is not unusual for people to see very different responses to GLP-1 medications, even when using them correctly.
"Some people simply don’t experience strong appetite suppression from semaglutide, even at the highest dose. This doesn’t mean they’re doing anything wrong - it reflects individual biology." -Alessandro Grenci, Superintendent Pharmacist at Medino
"If someone has been on a stable dose for several months with little to no response, it’s reasonable to discuss switching to a different GLP-1 medication."
"A sudden stall after early success is common. Small adjustments to diet, hydration, timing, or activity can help, but persistent hunger or weight regain warrants a review with a clinician."
Final Thoughts
When Wegovy isn’t working - or stops working - it can feel deeply discouraging. But the experiences shared here show that this is far more common than people expect. Some bodies simply respond differently to semaglutide, and for many, switching to another medication brings far better results.
It’s also clear that progress isn’t always linear. Plateaus, fluctuations, and periods of reduced appetite suppression happen even when people are doing everything right. In those moments, patience and consistency help - but so does knowing when it’s time to speak to a clinician about alternative options.
For anyone feeling stuck, the key message is this: it isn’t a personal failure. You’re not alone, your efforts still matter, and there are always next steps to explore.
