Xenical Orlistat Unveiled: A Comprehensive Review of User Experiences and Expert Insights

Reviewed and fact-checked by Alessandro Grenci, Superintendent Pharmacist. Read our editorial policy to see how we create informative, accurate content.

When it comes to weight loss, sometimes a helping hand is needed in addition to adjusting food intake and exercise. This is where Xenical Orlistat can help. Before deciding to take Xenical Orlistat, it's crucial to consider user experiences—something this article aims to explore in depth. Herein we will look at customer reviews to give an objective opinion of what to expect, the good and not-so-good experiences reported. Our analysis begins with an evaluation of review scores from various sources, followed by a summary of key themes within these reviews. We will then highlight a selection of reviews that stand out to us, positive and negative, before concluding the article with a section of comments from our superintendent pharmacist and an FAQ with the most commonly asked questions about Xenical Orlistat. Let’s jump in.

Review Score

We collected reviews from 3 different sources, the following: drugs.com, WebMD and The Independent Pharmacy. A total of 243 reviews were analysed. Here is the score across the platforms.


In general, it scores high with an average of 4.14 out of 5 - significantly higher than e.g. Wegovy which is a treatment with similar objectives but a different active ingredient and administration method.

Key findings

Here are the key trends and findings identified among the reviews:

  • Numerous users have experienced significant weight loss while using Orlistat 120mg Capsules, with some detailing the exact amount of weight they've lost, indicating a clear and measurable benefit from the medication.
  • The effectiveness of Orlistat appears to be enhanced when users adhere to a low-fat diet, with several testimonials emphasizing the need to avoid high-fat meals to reduce the risk of digestive side effects and to maximize weight loss results.
  • The convenience and discretion of the service associated with obtaining Orlistat are highly valued by users, suggesting that the process of acquiring the medication is user-friendly and respects privacy, which is an important factor for many individuals embarking on a weight loss journey.
  • Users commonly perceive Orlistat as a supportive tool rather than an all-encompassing solution, implying that successful weight loss involves a combination of medication, dietary adjustments, and lifestyle changes, including increased physical activity.
  • Digestive side effects, such as changes in bowel movements and the potential for oily stools, are noted by some users but are often described as manageable or a worthwhile trade-off for the benefits of weight loss, highlighting a general willingness to tolerate minor discomforts in pursuit of health goals.
  • The medication has been particularly helpful for individuals facing specific challenges, such as hormonal changes during menopause, suggesting Orlistat's versatility in aiding diverse populations with different underlying causes of weight gain.
  • The emphasis on incorporating exercise alongside Orlistat use underlines the importance of a holistic approach to weight loss, where medication, diet, and physical activity all play integral roles in achieving desired outcomes.
  • While many users openly recommend Orlistat and share their positive experiences, a few chose to withhold detailed comments, which might indicate a variety of reasons, including personal privacy concerns or simply a preference to endorse the product without sharing personal narratives.
  • The motivational aspect of using Orlistat, as reported by several users, points to not only the physical benefits of weight loss but also the psychological boost that comes with seeing tangible results, which can be a critical factor in maintaining long-term weight loss efforts.
  • Although most experiences shared are positive, the mention of a severe reaction in one review serves as a reminder that individual responses to medication can vary widely, and what works well for one person may not be suitable for another, underscoring the importance of personalized medical advice and monitoring.

Stand-out reviews

Here are some reviews that stand out to us, showing a positive experience when taking Orlistat:

  • Alison shared a straightforward and positive experience with Orlistat, indicating her satisfaction and intention to continue using the product: "They work really well I will definitely order more."
  • Sharon L highlighted the effectiveness of Orlistat during dietary lapses, mentioning that the medication works well for her even on days when she indulges, with only minor side effects: "I find these do work when I have naughty days. No problem with slight side effects."
  • Hollie praised not just the product but also the service associated with obtaining it, emphasizing the privacy and reliability that are important for users seeking discreet weight loss solutions: "Perfect, private and reliable service."
  • Graham provided a balanced view, acknowledging the benefits of Orlistat while also setting realistic expectations about its capabilities, suggesting it's a helpful tool rather than an outright solution: "They certainly help but not a miracle cure!"
  • Jose's review is a testament to the significant impact Orlistat can have on weight loss efforts, expressing great satisfaction with the results he has achieved: "It has helped me a lot to lose weight I am very happy."
  • Mariela shared an enthusiastic response to the rapid changes she observed, which serves as a motivating factor for continued use and further investment in the product: "I saw how my body changed in one week. I will get more."
  • Neil's review stands out for its mention of substantial long-term weight loss, attributing a significant transformation to the use of Orlistat, which underscores the potential of the medication when used consistently: "The medication has helped me no end in losing almost 40kg over a 7 month period."


Negative reviews

Some patients experienced side effects or did not achieve the weight loss they were hoping for. Here are some reviews highlighting a more negative experience:

  • Sinead: Felt disillusioned after not experiencing any weight loss after a month of use, despite needing to lose a significant amount due to her height and age: "I have been taking Xenical for 1 month & I have lost no weight. Feeling totally disillusioned."
  • nmallah: Reported minimal effects from Xenical over 15 days, with little to no change in weight and minimal oil excretion, contrasting with others' experiences: "I have been using xenical since more than 15 days and it is showing very little effect on me."
  • BettyZ: Expressed frustration over not losing weight after two weeks despite experiencing all the side effects associated with Xenical: "I have been taking this for 2 whole wks and haven't lost no weight! Although I have all the side effects."
  • Punter: Shared a particularly distressing experience with Xenical's side effects, including public accidents and the inconvenience of sudden urges to use the bathroom: "When the side effects hits you make sure you are close to a toilet. I've had 2 very unfortunate incidents."
  • Medya: Disappointed with the lack of weight loss after one and a half months of use, despite adhering to the medication's guidelines and experiencing its mechanisms: "Took it for one month and a half. Didn't lose even one pound!"
  • Anonymous: Described an uncomfortable sensation and fear of accidents due to the medication, leading to sleep disturbances and hygiene concerns: "Feels like something running around in my stomach, really bad wind, scared to poop in case of an accident."
  • Pandora: Experiencing heartburn as a side effect of Xenical, which wasn't listed in common side effects, causing discomfort and questioning the medication's suitability: "I have been taking this medicine for 2 weeks... I have a problem of heart burn after taking this medicine."

Pharmacist opinion

We then sat down with our Superintendent Pharmacist, Alessandro Grenci, to hear what he had to say about Xenical Orlistat:

As a pharmacist, I've seen firsthand the effectiveness of Xenical Orlistat in aiding weight loss. The product has shown proven results for many of my clients. However, it's essential to consult with a healthcare professional before beginning treatment to ensure it's suitable for your specific health needs. From my experience, when Xenical is combined with traditional weight loss tactics such as a balanced diet and regular exercise, it can significantly enhance the weight loss journey, offering a holistic approach to achieving and maintaining your weight loss goals.


In the following section our Superintendent Pharmacist Alessandro Grenci responds to some of the most frequently asked questions about Orlistat.

What is Xenical (Orlistat)?

Xenical, also known as Orlistat, is a prescription medication designed to assist individuals who are classified as overweight or obese in losing weight. It works by restricting the absorption of dietary fat in the body.

How does Xenical work?

Xenical (Orlistat) functions by inhibiting the action of lipase, an enzyme that breaks down fat in the intestine. This prevents the absorption of about one-third of the fat from the food you eat, which is then excreted from the body in the stool.

Are Xenical and Orlistat the same?

Yes, Xenical and Orlistat refer to the same medication. Xenical is the brand name, while Orlistat is the generic name. Both contain the same active ingredient and work in the same way.

How should Xenical be taken?

The recommended dose of Xenical is one 120-mg capsule three times a day with each main meal containing fat. It should be taken during or up to 1 hour after the meal. If a meal is missed or contains no fat, the dose can be omitted.

What diet should be followed while taking Xenical?

Patients should be on a nutritionally balanced, reduced-calorie diet that contains approximately 30% of calories from fat. The intake of fat, carbohydrates, and protein should be distributed over three main meals.

What are the common side effects of Xenical?

Common side effects include oily spotting, gas with discharge, faecal urgency, fatty/oily stool, oily evacuation, increased defecation, and faecal incontinence. These generally occur within the first weeks of treatment.

Can Xenical cause serious side effects?

Yes, though rare, Xenical can cause serious side effects such as severe liver damage, kidney stones, pancreatitis, and others. It's important to discuss the risks with your doctor.

Who should not take Xenical?

Xenical is not suitable for everyone. It should not be used by individuals who are pregnant or breastfeeding, those allergic to any of its ingredients, or those with certain digestive issues.

Can Xenical be taken with other medications?

Xenical can interact with certain medications, including cyclosporine and levothyroxine. It's important to manage the timing of these medications if taken alongside Xenical.

How effective is Xenical for weight loss?

Xenical, alongside a low-calorie diet and exercise, has been shown to be an effective weight loss aid. However, its effectiveness varies from person to person.

Can Xenical prevent weight regain after weight loss?

Orlistat is also used after weight loss to help prevent regaining the weight that has been lost.

What should I do if I miss a dose of Xenical?

If you miss a dose and your meal contains no fat or you skip a meal, you can omit the missed dose. Otherwise, take it as soon as you remember, as long as it's within 1 hour after the meal.

Are there any dietary supplements I should take while on Xenical?

Since Xenical can reduce the absorption of some fat-soluble vitamins, it's recommended to take a multivitamin supplement containing fat-soluble vitamins at least 2 hours before or after taking Xenical.

Can Xenical be used alongside other weight loss medications?

It is not recommended to use Xenical alongside other weight loss medications without consulting a healthcare provider.


Written by Christian Jakobsson