Are GLP-1 medications safe for people with kidney disease?
GLP-1 medications are generally safe for people with kidney disease, including those on dialysis or with kidney transplants, when used for weight loss or other approved purposes. UK Renal Pharmacy Group guidance supports their use across all stages of chronic kidney disease with standard dosing and minimal additional risk compared to the general population.
Key points:
- Reduced kidney function does not affect the safety or tolerability of GLP-1 medications.
- Gastrointestinal side effects can lead to dehydration, which may worsen kidney problems in advanced stages.
- Evidence shows potential kidney-protective benefits, particularly alongside weight loss.
- No dose adjustments needed for most kidney disease stages, but specialist advice is recommended for end-stage cases.
- Patient Group Direction (PGD) supply criteria may be more restrictive (e.g., exclusions by CKD stage, dialysis/transplant status, recent AKI, or need for specialist oversight)
This text has been fact-checked for accuracy by Sorin Romaniuc, Pharmacist at medino.