Can GLP-1 medications improve fertility in people with PCOS?
GLP-1 medicines are not licensed to treat PCOS or infertility, but some people with PCOS may see indirect fertility benefits if the treatment leads to weight loss and improved insulin resistance. Weight loss can help restore ovulation and improve menstrual regularity in some individuals. Evidence suggests GLP-1 medicines may improve ovulation and pregnancy outcomes when used before conception as part of a wider weight-management plan, but results vary.
GLP-1 medicines are not recommended during pregnancy, and you should stop treatment before trying to conceive. Discuss timing and contraception with a clinician.
Key points:
- GLP-1 medicines are not licensed for PCOS or fertility, but weight loss may improve ovulation and cycle regularity in some people with PCOS.
- Any fertility benefits are usually indirect and depend on individual response and weight change.
- Some studies suggest improved outcomes when used preconception in fertility pathways, but this is not a licensed indication.
- Treatment should be stopped before trying to conceive and avoided in pregnancy; seek clinician advice on timing.
This text has been fact-checked for accuracy by Sorin Romaniuc, Pharmacist at medino.