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Can GLP-1 medications reduce acne and hirsutism in PCOS?

GLP-1 receptor agonists may offer metabolic and hormonal benefits in women with PCOS. Studies show they support weight loss and can modestly reduce total testosterone, which may help some androgen-related symptoms. Evidence for improvement in hirsutism is mixed, and evidence for acne improvement is limited because it is not routinely measured in trials.

Key points:

• GLP-1 receptor agonists support weight loss and improve metabolic parameters in PCOS.
• Clinical studies show modest reductions in total testosterone levels.
• Some studies report small improvements in hirsutism scores, though findings vary.
• Evidence for acne improvement is limited and not consistently measured.
• Benefits are largely linked to weight loss and metabolic changes; direct hormonal effects remain under study.

This text has been fact-checked for accuracy by Sorin Romaniuc, Pharmacist at medino.