Can GLP-1 medications worsen existing depression?
GLP-1 medications can potentially worsen existing depression in some cases, as shown by patient reports and case studies where mood symptoms intensified after starting treatment. Evidence is mixed, with some studies finding no clear link or even mood improvements, while others note risks particularly in those with prior depression. Regulatory bodies like the FDA and EMA continue to review data due to inconsistent findings.
Key points:
- GLP-1 medications may worsen depression through effects on brain areas that regulate emotions.
- Physical side effects from these medications can indirectly affect mood.
- People with a history of depression face higher potential risk.
- Research shows mixed results, with some mood benefits and some worsening.
This text has been fact-checked for accuracy by Sorin Romaniuc, Pharmacist at medino.