Can I switch between Wegovy and Mounjaro?

Yes, switching between Wegovy and Mounjaro may be considered under clinical supervision if one treatment is not working well enough or is not well tolerated. Both are prescription-only.

Key points

In the STEP UP trial (72 weeks), semaglutide 7.2 mg achieved 18.7% average weight loss (regardless of adherence) and 20.7% among participants who adhered to treatment, versus 17.5% with semaglutide 2.4 mg.
Note: Wegovy’s currently licensed maintenance dose is 2.4 mg; 7.2 mg has been studied as a higher, not-routinely-available dose, so it should not be presented as an option unless and until it is authorised and prescribed appropriately.
A 7-day gap is commonly used when switching between weekly GLP-1 injections to reduce overlap and side effects, but the prescriber may individualise this.
The new medicine is usually started at the lowest dose, even if you were previously on a higher dose; however, a higher starting dose may be used on a case-by-case basis.

This text has been fact-checked for accuracy by Alessandro Grenci, Superintendent Pharmacist at medino.