Can I use ibuprofen or paracetamol while on Wegovy?

Yes, you can take both ibuprofen and paracetamol while on Wegovy (semaglutide), as there is no direct drug interaction between these painkillers and the medication. However, ibuprofen requires extra caution because both it and Wegovy can independently affect your stomach and digestive system, potentially causing additional discomfort. Paracetamol is generally considered the safer option as it does not carry the gastrointestinal risks associated with ibuprofen.

Key points:

Ibuprofen and paracetamol have no known direct interaction with Wegovy, but ibuprofen may irritate your stomach lining when combined with Wegovy's gastrointestinal side effects.
Paracetamol does not have the stomach-related risks of ibuprofen and has no known interaction with Wegovy.
If you need pain relief regularly while taking Wegovy, discuss this with your healthcare provider to explore alternative pain management strategies.
Ibuprofen should be taken with food or on a full stomach, and you should not exceed recommended doses.

This text has been fact-checked for accuracy by Sorin Romaniuc, Pharmacist at medino.