Does Mounjaro interact with the contraceptive pill?

Yes, Mounjaro (tirzepatide) does interact with the contraceptive pill and can reduce its effectiveness. The medication slows down stomach emptying, which decreases how much of the pill's hormones are absorbed into your bloodstream, with studies showing absorption can be reduced by up to 66%. Because of this interaction, regulatory bodies and manufacturers recommend using additional contraception methods to prevent unintended pregnancy.

Key points:

Mounjaro reduces the absorption of both combined pills and progestogen-only pills (mini-pills).
Use condoms or switch to a non-oral contraceptive method (such as a coil or implant) for four weeks after starting Mounjaro and for four weeks after each dose increase.
Mounjaro is not safe to use during pregnancy due to insufficient safety data, making reliable contraception essential during treatment.
Non-oral contraceptive methods like IUDs, implants, and injections are not affected by Mounjaro because they do not rely on stomach absorption.

This text has been fact-checked for accuracy by Sorin Romaniuc, Pharmacist at medino