What drugs interact with Cialis?
Cialis (tadalafil) interacts with several important drug classes, most notably nitrates used for heart conditions, other PDE5 inhibitors for erectile dysfunction, and blood pressure medications including alpha-blockers, all of which can cause dangerous drops in blood pressure. Certain antibiotics (clarithromycin, erythromycin, rifampin), antiseizure drugs (carbamazepine, phenobarbital, phenytoin), and antifungal medications (ketoconazole, itraconazole) can also interact by either increasing Cialis side effects or reducing its effectiveness. Additionally, recreational drugs including poppers (amyl nitrite), nitrous oxide, methamphetamines, MDMA, ketamine, cannabis, opioids, and cocaine can cause serious adverse effects such as stroke, heart attack, or dangerous blood pressure drops.
Key points:
- Nitrates and other blood pressure medications pose the greatest risk by causing potentially life-threatening drops in blood pressure
- Certain antibiotics and antiseizure drugs alter how Cialis is processed in the body, affecting its safety or effectiveness
- Recreational drugs combined with Cialis can trigger severe cardiovascular events and other serious complications
- You should inform your doctor or pharmacist of all medications and substances before taking Cialis
This text has been fact-checked for accuracy by Sorin Romaniuc, Pharmacist at medino.