Which has fewer side effects: Mounjaro or Wegovy?
Overall, the side effect profiles are similar. Both commonly cause digestive side effects, especially during dose increases. In the main head-to-head weight loss trial, slightly fewer people stopped tirzepatide (Mounjaro) due to side effects than semaglutide 2.4 mg (Wegovy) (6.1% vs 8.0%).
Key points:
- Both mainly cause gastrointestinal side effects such as nausea, diarrhoea, vomiting, constipation, and indigestion.
- Most side effects are mild to moderate and tend to improve over time.
- Discontinuation due to side effects was slightly lower with Mounjaro than Wegovy in a head-to-head trial (6.1% vs 8.0%).
- Individual tolerance varies, and higher doses are more likely to cause side effects.
This text has been fact-checked for accuracy by Sorin Romaniuc, Pharmacist at medino.