Which medication causes more weight loss: Mounjaro or Wegovy?

Mounjaro causes more weight loss than Wegovy based on clinical trial results. In trials, people on the highest dose of Mounjaro lost up to 22.5% of their starting weight after 72 weeks, while those on Wegovy's maintenance dose lost around 17-21% after 68-72 weeks. Sources agree Mounjaro shows slightly greater average weight loss, though direct head-to-head comparisons are lacking.

Key points:

  • Mounjaro led to up to 22.5% weight loss in trials over 72 weeks.
  • Wegovy achieved around 17-21% weight loss in trials over 68-72 weeks.
  • Mounjaro is slightly more effective overall according to multiple sources.
  • Results vary by individual and require lifestyle changes alongside medication.

This text has been fact-checked for accuracy by Alessandro Grenci, Superintendent Pharmacist at medino.