Wegovy Pill (Semaglutide Tablet)
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Description
What is the Wegovy Pill?
The Wegovy pill is an oral version of Wegovy weight-loss injections. Both contain semaglutide, which is designed to support weight loss alongside a balanced diet and increased physical activity. Semaglutide mimics a hormone called glucagon-like peptide-1 (GLP-1), which helps to slow the rate at which food leaves the stomach, increase feelings of fullness, and reduce calorie intake.
In the OASIS 4 clinical trial, adults taking oral semaglutide experienced an average weight reduction of 14% over 64 weeks, with approximately one in four losing 20% or more of their starting body weight.¹
UK Availability
The Wegovy pill has been approved in the United States and launched in early 2026. Before it can become available in the UK, it must be approved by the Medicines and Healthcare products Regulatory Agency (MHRA). A UK approval decision is expected around mid-2026, although timelines may change.
Eligibility (subject to clinical assessment)
If approved in the UK, the Wegovy tablet is expected to be prescribed to adults who:
- have a BMI of 30 or above, or
- have a BMI of 27 or above with at least one weight-related health condition.
You should not use Wegovy if you are pregnant, planning to get pregnant, or breastfeeding.
Wegovy Pill vs Wegovy Injection
| Feature | Wegovy Pill | Wegovy Injection |
|---|---|---|
| How taken | Oral tablet | Injected under the skin |
| Frequency | Once daily | Once weekly |
| Dose strengths | 1.5mg, 4mg, 9mg, 25mg | 0.25mg, 0.5mg, 1mg, 1.7mg, 2.4mg, 7.2mg |
| Average weight loss | ~14% over 64 weeks (OASIS 4)¹ | ~15% over 68 weeks (STEP 1) |
Wegovy Pill vs Mounjaro
| Feature | Wegovy Pill | Mounjaro Injection |
|---|---|---|
| Active ingredient | Semaglutide | Tirzepatide |
| How it works | Mimics the GLP-1 hormone | Mimics both GLP-1 and GIP hormones |
| How taken | Oral tablet, once daily | Injection under the skin, once weekly |
| Average weight loss | ~14% over 64 weeks (OASIS 4)¹ | ~22.5% over 72 weeks (SURMOUNT-4)² |
¹ OASIS 4 trial, November 2025. ² SURMOUNT-4 trial. Individual results vary.
Consultation Process
This treatment requires an online consultation for review by our medical team. The decision to supply will be based on whether our medical team are satisfied that it will be safe, appropriate, and effective for you.
1. Complete a health questionnaire
2. Medical team review
3. Identity verification
4. Supporting evidence
You may be asked to provide confirmation of weight, height, or medical history to support safe supply.
Purchasing this medication does not guarantee supply. If supply is not appropriate, your order will be refunded.
Ingredients
Active ingredient: Semaglutide
Other ingredients: Salcaprozate sodium (SNAC) and magnesium stearate.
Available strengths: 1.5mg, 4mg, 9mg, 25mg
Pack size: 1 month supply
Manufacturer: Novo Nordisk. For the most up-to-date list of ingredients, please check the Patient Information Leaflet inside the box.
Usage and Instructions
- Take your Wegovy tablet first thing in the morning on an empty stomach.
- Swallow the tablet whole with up to 100ml of water only. Taking it with more may reduce absorption and make it less effective.
- Wait at least 30 minutes before eating, drinking, or taking other medicines.
- Do not crush, chew, or split the tablet.
Wegovy tablets are always started at a low dose and increased gradually by your clinical team. This allows your body to adjust and keeps side effects to a minimum.
Missed dose: If you miss a dose, simply skip that day and take the next day's dose as usual. Do not take a double dose.
Use with alcohol: Caution is recommended when drinking alcohol whilst taking this medication.
Warnings
- Thyroid cancer: Do not use Wegovy if you or any family member have ever had medullary thyroid carcinoma (MTC), or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Tell your healthcare professional if you notice a lump in your neck, hoarseness, trouble swallowing, or shortness of breath.
- Allergic reactions: Do not use Wegovy if you have had a serious allergic reaction to semaglutide or any of its ingredients.
- Pancreatitis: Discontinue immediately if suspected. Seek urgent help if you experience severe abdominal pain spreading to your back.
- Gastrointestinal effects: May cause stomach issues and, in rare cases, dehydration. Drink enough fluids if you experience persistent nausea, vomiting, or diarrhoea.
- Hypoglycaemia: Increased risk if taken alongside insulin or certain diabetes medicines. Your doctor may need to adjust your other medications.
- Diabetic retinopathy: Rapid improvements in blood sugar control can temporarily worsen diabetic retinopathy. Monitor your eye health closely.
- Pregnancy and breastfeeding: Do not use during pregnancy or breastfeeding.
- Other medicines: Tell your prescriber about all medicines you are taking, particularly other weight loss treatments, other GLP-1 medicines, insulin, diabetes medicines, and warfarin.
For a full list of warnings, please see the Patient Information Leaflet.
Side Effects
Like many medicines, Wegovy may cause side effects. Common side effects include:
- Nausea
- Vomiting
- Diarrhoea
- Constipation
- Stomach (abdominal) pain
- Heartburn
- Dizziness
- Fatigue
Stomach side effects are most common at the start of treatment and often settle over time as your body adjusts.
Follow the prescribed dosage and inform your prescriber of any concerns. For a full list of side effects, please see the Patient Information Leaflet.
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