Napralief 250mg gastro-resistant tablets contain naproxen, a non-steroidal anti-inflammatory drug (NSAID) used for the short-term relief of pain and inflammation. Napralief is used to relieve muscular pain, joint pain, sprains, strains, back pain, neck pain, pain associated with sports injuries, and period pain in adults.

Each gastro-resistant tablet contains 250mg of naproxen and is designed to pass through the stomach before dissolving in the intestine. This may help reduce stomach irritation associated with some anti-inflammatory medicines. The tablets provide convenient short-term dosing for acute painful conditions and can help reduce swelling, stiffness, and discomfort associated with inflammation.

Napralief tablets are suitable for adults requiring temporary relief of inflammatory pain where treatment with an NSAID is appropriate. The medicine should be used at the lowest effective dose for the shortest duration necessary to control symptoms.

Patient information leaflet

Main ingredients: Naproxen 250mg per gastro-resistant tablet

Excipients: Lactose monohydrate, maize starch, povidone, sodium starch glycolate, glycerol, magnesium stearate, methacrylic acid copolymer, triethyl citrate, talc, titanium dioxide (E171), simeticone emulsion

Napralief 250mg gastro-resistant tablets are used for the short-term relief of muscular pain, joint pain, sprains, strains, lower back pain, neck pain, pain caused by sports injuries, and period pain in adults.

Adults should take two tablets initially, followed by one tablet after 6 to 8 hours if needed on the first day. On the second and third day, one tablet may be taken every 6 to 8 hours if required. Do not take more than three tablets in any 24-hour period and do not use for longer than three days unless advised by a doctor.

The tablets should be swallowed whole with water and preferably taken with or after food. Gastro-resistant tablets should not be crushed, broken, or chewed.

If vomiting occurs shortly after taking a dose, seek advice from a pharmacist or doctor before taking another tablet.

Avoid taking other NSAIDs, including ibuprofen or high-dose aspirin, while using Napralief. Alcohol may increase the risk of stomach irritation. Use the lowest effective dose for the shortest possible duration needed to control symptoms.

Do not take Napralief if you are allergic to naproxen, aspirin, ibuprofen, or other NSAIDs, or if these medicines have previously caused asthma, wheezing, nasal swelling, or allergic reactions.

Do not take this medicine if you currently have, or have previously had, stomach ulcers, stomach bleeding, or perforation related to NSAID use. Napralief must not be used in severe heart failure, severe liver problems, severe kidney problems, or during the last three months of pregnancy.

Speak to a doctor or pharmacist before use if you have asthma, high blood pressure, heart disease, inflammatory bowel disease, bleeding disorders, diabetes, high cholesterol, or if you smoke. Older adults may be more likely to experience side effects affecting the stomach or bowel.

Naproxen may affect fertility in women and is not recommended for women trying to become pregnant. During the first six months of pregnancy, naproxen should only be used if clearly necessary and advised by a healthcare professional. Naproxen passes into breast milk and should generally be avoided while breastfeeding unless advised otherwise by a doctor.

Napralief can interact with a number of medicines including anticoagulants, corticosteroids, antidepressants, blood pressure medicines, lithium, methotrexate, ciclosporin, and other painkillers or anti-inflammatory medicines.

This medicine may cause dizziness, drowsiness, tiredness, visual disturbances, or difficulty concentrating. Do not drive or operate machinery if affected.

Stop taking the tablets and seek urgent medical attention if you develop signs of an allergic reaction, severe skin rash, breathing difficulties, black stools, vomiting blood, chest pain, sudden weakness, speech problems, or severe abdominal pain.

Very common side effects may include indigestion, heartburn, stomach discomfort, nausea, and headache.

Common side effects may include abdominal pain, constipation, diarrhoea, wind, dizziness, drowsiness, skin rash, itching, ringing in the ears, swelling of the hands or feet, and increased sweating.

Uncommon side effects may include stomach ulcers, inflammation of the stomach lining, vomiting, mouth ulcers, difficulty sleeping, depression, abnormal dreams, palpitations, changes in liver function tests, visual disturbances, and sensitivity to sunlight.

Rare side effects may include serious allergic reactions, severe skin reactions including blistering or peeling skin, asthma worsening, liver problems, kidney disorders, meningitis, pancreatitis, blood disorders, and severe gastrointestinal bleeding or perforation.

Frequency not known side effects include DRESS syndrome, fixed drug eruption, confusion, hallucinations, and inflammation of blood vessels.

Seek urgent medical attention if you develop swelling of the face or throat, difficulty breathing, severe skin reactions, black or bloody stools, vomiting blood, chest pain, sudden weakness on one side, severe stomach pain, yellowing of the skin or eyes, or signs of infection such as fever with sore throat.