Panmigrol Migraine Pain Relief 250 mg / 250 mg / 65 mg Film-Coated Tablets (20 Tablets) is a combination pain relief medicine used for the acute treatment of headaches and migraine attacks, with or without aura, in adults aged 18 years and over.

Each film-coated tablet contains three active ingredients: acetylsalicylic acid (aspirin) 250 mg, paracetamol 250 mg and caffeine 65 mg.

Aspirin and paracetamol help reduce pain and fever, while aspirin also reduces inflammation. Caffeine is a mild stimulant that enhances the pain-relieving effects of aspirin and paracetamol.

Panmigrol is used for headaches and migraine attacks, including migraine symptoms such as headache, nausea, sensitivity to light and sound, and difficulty carrying out normal daily activities.

The tablets are taken when symptoms appear, with additional doses permitted at intervals of 4 to 6 hours where necessary. Each dose should be taken with a full glass of water.

The pack contains 20 film-coated tablets and is intended for short-term, occasional use. Do not exceed 6 tablets in 24 hours.

This medicine is not suitable for children or adolescents under 18 years of age. A pharmacist can provide further advice about its appropriate use, precautions and possible interactions with other medicines.

Always read the Patient Information Leaflet before use.

Patient Information Leaflet

Main ingredients: Each film-coated tablet contains acetylsalicylic acid (aspirin) 250 mg, paracetamol 250 mg, caffeine 65 mg.

Excipients: Low-substituted hydroxypropyl cellulose, microcrystalline cellulose (E460), stearic acid, hypromellose (E464), titanium dioxide (E171), propylene glycol, benzoic acid (E210), carnauba wax (E903).

Panmigrol Migraine Pain Relief is used for the acute treatment of headaches and migraine attacks, with or without aura, in adults aged 18 years and over.

Adults aged 18 years and over:

For headaches: Take 1 tablet with a full glass of water when headache pain appears. If necessary, take a further 1 tablet after 4 to 6 hours.

For more intense headache pain, take 2 tablets with a full glass of water when symptoms appear. If necessary, take a further 2 tablets after 4 to 6 hours.

Do not use for more than 4 days for headache without consulting a doctor.

For migraine: Take 2 tablets with a full glass of water when migraine symptoms or migraine aura appear. If necessary, take a further 2 tablets, allowing 4 to 6 hours between doses.

If migraine symptoms have not improved within 2 hours of the first 2-tablet dose, seek medical advice.

Do not use for more than 3 days for migraine without consulting a doctor.

Maximum daily dose: Do not take more than 6 tablets in any 24-hour period. This is equivalent to 1,500 mg aspirin, 1,500 mg paracetamol and 390 mg caffeine.

Administration: Take the tablets by mouth with a full glass of water. Use the smallest dose necessary to relieve symptoms and continue for the shortest possible time.

Children and adolescents: Do not give this medicine to anyone under 18 years of age.

Older adults: No specific dose adjustment is recommended, but older adults, particularly those with low body weight, should seek medical or pharmacist advice before use.

Kidney or liver problems: Consult a doctor before use. Dose intervals or duration may need adjustment. Do not take this medicine if you have severe liver or kidney problems.

Missed dose: Take the dose when remembered if it is still needed. Do not take a double dose to make up for a forgotten dose, and do not exceed the maximum daily dose.

Persistent symptoms: Speak to a doctor if symptoms worsen, migraine continues beyond 3 days, or headache continues beyond 4 days.

Frequent use of painkillers can worsen headaches. Seek medical advice if headaches become more frequent or if you regularly need headache medication.

Always follow the Patient Information Leaflet and seek advice from a pharmacist or doctor if unsure about appropriate use.

Do not take Panmigrol Migraine Pain Relief if you:

• Are allergic to aspirin, paracetamol, caffeine or any of the other ingredients.
• Have experienced an allergic reaction, asthma attack, wheezing, swelling or hives after taking aspirin, ibuprofen, diclofenac or other non-steroidal anti-inflammatory medicines (NSAIDs).
• Have an active stomach or intestinal ulcer, gastrointestinal bleeding, or a history of peptic ulceration.
• Have haemophilia or another bleeding disorder.
• Have severe heart failure, severe liver impairment or severe kidney impairment.
• Are in the last 3 months of pregnancy.
• Are taking another medicine containing paracetamol.

Speak to a doctor before use if you:

• Have not previously been diagnosed with migraine, experience unusual migraine symptoms, or have a migraine severe enough to require bed rest.
• Experience vomiting with migraine attacks or have a headache different from your usual migraine.
• Develop headaches following a head injury, physical exertion, coughing or bending.
• Experience persistent or chronic headaches, or develop your first headache after the age of 50.
• Have liver or kidney problems, are underweight, malnourished, dehydrated or regularly drink alcohol.
• Have asthma, hay fever, nasal polyps or other chronic respiratory conditions.
• Have gout, diabetes, an overactive thyroid, an irregular heartbeat or uncontrolled high blood pressure.
• Have glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Have a history of stomach problems, unusual bleeding or heavy menstrual bleeding.
• Have recently undergone surgery or are due to undergo surgery, including dental procedures.
• Have a severe infection or serious illness, particularly if taking flucloxacillin.

Pregnancy and breastfeeding: This medicine is not recommended during pregnancy. If you are pregnant, think you may be pregnant or are planning a baby, inform your doctor and do not take Panmigrol.

Do not take during the last 3 months of pregnancy, as it may harm the unborn baby or cause complications during delivery.

Do not take while breastfeeding, as it may be harmful to your infant.

Aspirin belongs to a group of medicines that may temporarily impair female fertility. This effect is reversible when the medicine is stopped.

Medicine interactions: Do not combine Panmigrol with other medicines containing aspirin or paracetamol. Avoid using it with other NSAIDs unless advised by a doctor.

Speak to a pharmacist or doctor before use if taking other medicines, particularly blood thinners such as warfarin, antiplatelet medicines, corticosteroids, antidepressants, methotrexate, epilepsy medicines, diabetes medicines, blood pressure medicines, diuretics or certain antibiotics, including flucloxacillin.

This is not a complete list of possible interactions.

Alcohol: Avoid alcohol while taking this medicine because of the increased risk of liver damage and gastrointestinal bleeding. If you regularly consume 3 or more alcoholic drinks daily, consult your doctor before use.

Caffeine: Limit additional caffeine from coffee, tea, energy drinks, food and other medicines. Excess caffeine may cause nervousness, irritability, difficulty sleeping and a rapid heartbeat.

Driving and using machines: This medicine is not known to affect driving ability. However, if you experience dizziness or drowsiness, do not drive or operate machinery.

Serious allergic reactions: Stop taking the medicine and seek immediate medical attention if you develop swelling of the face or throat, breathing difficulties, severe skin reactions or chest pain accompanied by allergic symptoms.

Bleeding and liver problems: Seek urgent medical attention if you develop severe abdominal pain, vomit blood, pass black or bloody stools, experience unexplained bleeding, or develop yellowing of the skin or eyes.

Metabolic acidosis: Seek immediate medical help if you experience a combination of deep or rapid breathing, drowsiness, nausea, vomiting and loss of appetite, particularly if severely unwell or taking flucloxacillin.

Medication overuse headache: Taking this medicine too frequently may worsen headaches. Using it on more than 10 days per month with chronic headaches over a period exceeding 3 months may indicate medication overuse. Seek medical advice if this occurs.

Overdose: If you take more than the recommended dose, seek medical attention immediately, even if you feel well. Paracetamol overdose can cause serious delayed liver damage, even when initial symptoms are absent.

Storage: Keep out of the sight and reach of children. Do not store above 25°C. Do not use after the expiry date stated on the packaging.

Read the Patient Information Leaflet carefully before taking this medicine.

Like all medicines, Panmigrol Migraine Pain Relief may cause side effects, although not everybody experiences them.

Stop taking Panmigrol and seek immediate medical attention if you experience a serious allergic reaction, severe skin reaction, gastrointestinal bleeding or other serious symptoms listed above.

Some side effects may be serious even when their frequency is not known.

If you experience any side effects, including effects not listed here, speak to your doctor or pharmacist. Suspected side effects can also be reported through the MHRA Yellow Card Scheme.