What happens in your body if you skip doses of Mounjaro?
If you skip doses of Mounjaro (tirzepatide), the levels of medication in your body fall, which can reduce its effectiveness for weight management. Mounjaro works best when taken once weekly, as this keeps appetite control and feelings of fullness consistent. Missing one or more doses may cause hunger to increase, cravings to return, and weight loss to slow or plateau. If treatment is interrupted for several weeks, restarting may increase the chance of side effects such as nausea, as your body may need time to readjust. In the UK, guidance advises taking a missed dose within 4 days if possible; if more than 4 days have passed, the missed dose should be skipped and the next dose taken as scheduled. You should not take two doses close together, and medical advice is recommended if multiple doses are missed.
- Appetite control and fullness may reduce as drug levels drop.
- Weight loss may slow or become inconsistent if doses are missed.
- Side effects may be more likely when restarting after a longer break.
- A missed dose can be taken within 4 days; otherwise, skip it and continue as normal.
- Do not double doses, and seek medical advice if you miss more than one dose.
This text has been fact-checked for accuracy by Sorin Romaniuc, Pharmacist at medino.