Why Some Patients Prefer Wegovy Over Mounjaro
When it comes to modern weight-loss medications, two names dominate the conversation: Wegovy (semaglutide) and Mounjaro (tirzepatide). Both have been hailed as breakthroughs, helping people curb appetite, reduce food cravings, and achieve substantial weight loss.
On paper, clinical trials suggest Mounjaro is the more powerful drug. But in online forums like Reddit, where patients share raw, unfiltered experiences, the story looks different. Many users continue to favour Wegovy, citing familiarity, affordability, tolerability, and personal responsiveness as just as important as trial results.
Familiarity and Comfort with Wegovy
For many, the choice came down to trust and recognition. Semaglutide has been prescribed for years under the brand name Ozempic for type 2 diabetes, so Wegovy felt like the safer, more familiar step.
"I chose Wegovy because I had heard about Ozempic a lot. I’d never heard of Mounjaro so I was just more comfortable starting with the brand I was more familiar with, even though it did say Mounjaro had a slightly higher success rate." – u/Queen_Banana
That sense of reassurance mattered more than the promise of faster weight loss. For some, choosing Wegovy was about confidence in a drug with a longer track record.
Cost and Practicality
Affordability was another deciding factor. Patients often note that depending on the provider, Wegovy can be the cheaper option in the UK.
"I started in November 2024 and picked Wegovy because it was cheaper. It’s working for me with slow steady weight loss so I don’t see any reason to change. Maybe in the future if it loses effectiveness, I’ll consider trying Mounjaro." – u/sandra_nz
Others highlighted how cost shaped their decision to switch:
"I stopped Wegovy because I couldn’t afford the maintenance dose of 2.4mg anymore and weight loss slowed down. Now that Mounjaro is available in the UK I thought why not give it a go." – u/Day1million
While some users find Mounjaro cheaper at higher doses, for many starting out, Wegovy fits better within their budget.
The Side Effect Trade-Off
Side effects often tip the balance in favour of one drug over the other. Some users say they tolerate Wegovy better, while others find Mounjaro easier.
"I was on Ozempic/Wegovy for 18 months. I felt fantastic. Odd tummy trouble but overall my health was brilliant. I only swapped to Mounjaro as my weight loss stopped… I have more side effects on Mounjaro — low blood pressure, hot and cold flushes, tired. When I reach goal I am hoping to maintain on Wegovy rather than Mounjaro." – u/Lady_Hamthrax
For others, it was the opposite:
"I started on Wegovy and lost 3 stone… I switched to Mounjaro… Side effects have been slightly less on MJ. I had sulphur burps on Wegovy that I haven’t had on MJ." – u/IllustriousNeat6597
These differences underline that there is no universal "better" option — only what works for each person.
Effectiveness Isn’t One-Size-Fits-All
Despite the clinical edge Mounjaro shows, real-world responses vary widely. Some find Wegovy more effective.
"I reached 1.7mg on Wegovy and lost 50lbs. After a very very long stall decided to change to Mounjaro… I have now been on Mounjaro for 2 months… absolutely zero appetite suppression at all. No nasty side effects which is brilliant but absolutely zero appetite suppression." – u/LettuceMountain5512
Others noted Mounjaro required higher doses before results appeared:
"I didn’t get much suppression or lose much weight until I got to 7.5mg. I’m now on 10mg and have been for 3 months. It will kick in if you stick with it." – u/IllustriousNeat6597
"My best mate switched after stalling on Wegovy… She said it was slow at first but got better once she was on 5mg and above." – u/RunsWithGlueSticks
Still, some users preferred Wegovy’s rhythm:
"With Wegovy it feels like the dose gets stronger and stronger peaking at 3 days after injection… With Mounjaro I feel the strength instantly but as the week goes on it gets weaker. This makes me think Wegovy worked better for me." – u/Day1million
Reproductive Health and Contraception
For women, Mounjaro’s interaction with oral contraceptives was a concern that pushed some toward Wegovy.
"I chose Wegovy because it’s cheaper and doesn’t affect the birth control pill like Mounjaro." – u/InnerButterflyy
This factor, often overlooked in clinical data, illustrates how lifestyle and safety considerations affect real-world choices.
Stability, Control, and Lifestyle Fit
Not everyone seeks the fastest results. For many, Wegovy’s appeal lies in its predictability and stability.
"Being part of these communities I feel a lot better informed now and would definitely consider switching to Mounjaro in the future if my weight loss stalls… But so far I’m happy losing slowly with minimal side effects." – u/Queen_Banana
"I’ve had good results with Wegovy and have had no reason to ‘jump ship’… A couple of my friends have started these meds… they have gone straight to Mounjaro as they said the trial results are better." – u/sickiesusan
For many, the "best" drug is the one that fits smoothly into daily life.
Beyond Clinical Trials: The Bigger Picture
Taken together, these patient voices show that averages don’t define individuals. Clinical data might favour Mounjaro, but lived experience often tells a different story.
Why some patients still prefer Wegovy:
- Familiarity and long-term trust.
- Lower cost at certain doses.
- Side effects they find easier to manage.
- No impact on contraception.
- A weekly rhythm that feels more stable.
"Honestly, whichever one you can find or afford is what I’d go with. Any of these will likely help you lose weight… don’t overthink it." – u/ladyeclectic79
Expert Insight
Superintendent Pharmacist Alessandro Grenci emphasises that while both Wegovy and Mounjaro are effective, the best option depends on the individual.
"Clinical trials can tell us which medicine looks stronger on average, but they don’t capture the day-to-day reality for patients. In practice, people respond differently: some feel better on Wegovy, others on Mounjaro. The right choice is always the one that balances effectiveness with safety, tolerability, and lifestyle fit for that individual." – Alessandro Grenci, Superintendent Pharmacist
To sum up
Wegovy may not carry the same bold trial headlines as Mounjaro, but for many patients it remains the more comfortable and reliable choice. Its familiarity, affordability, and tolerability provide a kind of stability that numbers alone can’t capture.
As one Redditor put it: "You can’t really go wrong with whichever you try first."
In the end, the choice between Wegovy and Mounjaro isn’t about a universal "winner." It’s about finding what works best for the individual — their body, their budget, and their life.
