Clotrimazole Vaginal Tablet contains the active ingredient clotrimazole, which is an antifungal medicine used to treat infections with fungi and yeasts, such as Candida Fungi (thrush infection).

Clotrimazole kills the Candida fungi causing the thrush infection by interfering with their cell membranes. The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. Clotrimazole makes holes appear in these membranes, which kills the fungi and clears up the infection.

The pessary is inserted into the vagina to allow the clotrimazole to act directly in the area of infection.

Contains Lactose.

Active Ingredient: Clotrimazole 500mg

Other ingredients: Adipic Acid, Microcrystalline Cellulose, Pregelatinised MaizeStarch, Sodium Hydrogen Carbonate, Stearic Acid, Lactose, Polysorbate 80, Magnesium Stearate, Maize Starch, Colloidal Silicon Dioxide.

Read the leaflet before use.

To be used as directed by your doctor.

Medical advice should be sought if this is the first time the patient has experienced symptoms of candidal vaginitis.

Before using Clotrimazole 500mg Pessary, medical advice must be sought if any of the following are applicable:

• more than two infections of candidal vaginitis in the last six months.
• previous history of a sexually transmitted disease or exposure to partner with sexually transmitted disease.
• pregnancy or suspected pregnancy.
• aged under 16 or over 60 years.
• known hypersensitivity to imidazoles or other vaginal anti-fungal products.

Clotrimazole 500mg Pessay should not be used if the patient has any of the following symptoms whereupon medical advice should be sought:

• irregular vaginal bleeding.
• abnormal vaginal bleeding or a blood-stained discharge.
• vulval or vaginal ulcers, blisters or sores.
• lower abdominal pain or dysuria.
• any adverse events such as redness, irritation or swelling associated with the treatment.
• fever or chills.
• nausea or vomiting.
• diarrhoea.
• foul smelling vaginal discharge.

Patients should be advised to consult their physician if the symptoms have not been relieved within one week of using Clotrimazole 500mg Pessary. The pessaries can be used again if the candidal infection returns after 7 days. However, if the candidal infection recurs more than twice within six months, patients should be advised to consult their physician.

Laboratory tests have suggested that, when used together, this product may cause damage to latex contraceptives. Consequently, the effectiveness of such contraceptives may be reduced. Patients should be advised to use alternative precautions for at least five days after using this product.

Clotrimazole can be used during pregnancy, but only under the supervision of a physician or midwife. During pregnancy the pessary should be inserted without using an applicator.

The following are some of the side effects that are known to be associated with Clotrimazole pessaries:

• Vaginal irritation, for example burning, stinging, itching, redness, rash, blistering or peeling. Stop using the pessaries and consult your doctor if you have a severe reaction to them.
• You may experience some pelvic or abdominal pain or vaginal bleeding after using the pessaries.