What is Foundayo?

Foundayo tablets contain orforglipron and are a prescription-only oral medicine used for weight management in eligible adults. Foundayo must be used alongside a reduced-calorie diet and increased physical activity.

Orforglipron acts similarly to a natural hormone called glucagon-like peptide-1 (GLP-1), which regulates blood sugar, appetite, and metabolism. It works on receptors in the brain involved in appetite control, helping you feel fuller for longer, experience fewer food cravings, and reduce your overall food intake.

In clinical studies for Foundayo, adults receiving the highest maintenance dose of 17.2 mg once daily, alongside a reduced-calorie diet and increased physical activity, had an estimated average reduction in body weight of 12.4% after 72 weeks. This result relates to the highest maintenance dose, not the starting dose. Individual responses vary, and not everyone will lose the same amount of weight.

Who is Foundayo intended for?

Foundayo tablets are licensed for weight management in adults with an initial body mass index of:

• 30 kg/m² or above, which is classified as obesity; or
• 27 kg/m² to below 30 kg/m², which is classified as overweight, when at least one weight-related health problem (such as high blood pressure or high cholesterol) is also present.

Foundayo tablets are not recommended for children or adolescents under 18 years of age, as their safety and effectiveness have not been established in this age group.

Foundayo starting dose

Foundayo 0.8 mg is the once-daily starting dose used during the first month of treatment to allow your body to adjust gently. The dose is then usually increased gradually:

• Month 1: 0.8 mg once daily.
• Month 2 onwards: 2.5 mg once daily, with potential further increases every 30 days.

Each dose level is normally used for at least one month (30 days). Dose increases should only be made in accordance with your prescribed dosing schedule, depending on your response and tolerance, up to a maximum maintenance dose of 17.2 mg daily.

Do not take more than one tablet per day to obtain the effect of a higher dose.

How to take Foundayo tablets

Take one Foundayo tablet once daily:

• Swallow the tablet whole.
• Do not split, crush, or chew the tablet.
• No food or water restrictions: Unlike other oral GLP-1 medicines, Foundayo can be taken at any time of day, with or without food or water, making it easy to fit seamlessly into your routine.

Taking your tablet at the same time each day can help you remember to take it.

FAQs

How do I take the Foundayo pill?

Take one tablet daily as directed by your healthcare provider. Because Foundayo has no fasting or water restrictions, it can be taken at any time of day, with or without meals. Swallow the tablet whole; do not break, crush, or chew it.

How Much Weight Should I Expect to Lose on the Foundayo Pill?

Individual results vary, but clinical studies of orforglipron have shown significant weight-loss potential when combined with a reduced-calorie diet and increased physical activity. Studies report that participants treated with the highest maintenance dose of Foundayo achieved an average weight loss of 12.4% of their body weight over 72 weeks. Your specific results will depend on factors such as your starting weight, dosage, lifestyle habits, and adherence to treatment.

When Will I Start Noticing Results?

Many users begin to report reduced hunger and see initial weight loss within the first few weeks of treatment. Weight loss results vary, but consistent use alongside a balanced diet and regular physical activity will provide ongoing, dose-dependent weight loss over time.

What Should I Do if I Miss a Dose?

If you miss a dose, take it as soon as possible. However, do not double up or take extra tablets to make up for a missed dose. Always follow the specific instructions provided by your healthcare provider or the patient information leaflet.

Are There Any Common Side Effects?

Some users may experience nausea, vomiting, or diarrhoea, particularly when first starting treatment or when increasing the dose. These gastrointestinal effects are often mild to moderate and typically temporary as the body adjusts to the medication.

Patient Information Leaflet

Our service does not include a prescription. Instead, your treatment is supplied under a legal framework known as a Patient Group Direction (PGD). The process follows these steps:

1. Complete a health questionnaire

Provide detailed information about your health and medical history.

2. Pharmacist review

A pharmacist will review your responses and may contact you by phone or video call if further information is required to support safe supply.

3. Private consultation

All interactions are confidential. This provides an opportunity to discuss any questions and ensure appropriate use of the treatment.

4. Identity verification

You may be asked to provide identification to confirm that you are the intended user. This is typically required for your first order only.

5. Supporting evidence

You may be asked to provide relevant information, such as confirmation of weight, height, or medical history, to support safe supply.

Your GP will be notified of your request and the outcome of the supply decision, whether the treatment is supplied or not, to support continuity of care.

Purchasing this medication does not guarantee supply. The decision to supply is made by the pharmacist based on the information provided. If supply is not appropriate, your order will be refunded.

Active ingredient: Each film-coated tablet contains orforglipron (as orforglipron calcium), equivalent to 0.8 mg of orforglipron.

Foundayo 0.8 mg is the starting dose used when you first begin treatment:

1. 0.8 mg once daily for at least 30 days.
2. Your prescriber will normally then increase your dose to 2.5 mg once daily, and may increase it further, up to a maximum of 17.2 mg once daily, at intervals of at least 30 days, based on how well it's working for you and how well you tolerate it.

Swallow the tablet whole; do not break, crush or chew it. It can be taken at any time of day, with or without food or water.

If you miss a dose, take it as soon as you remember; do not take a double dose to make up for the one you missed.

Store the tablets in their original packaging, as Foundayo is sensitive to light.

• Do not take Foundayo if you are allergic to orforglipron or any of the other ingredients in the tablet.
• Not recommended during pregnancy, as the effects on an unborn baby are not known. Use effective contraception and stop treatment at least 3 weeks before trying to conceive. Foundayo may reduce the effectiveness of oral contraceptives, so barrier contraception (such as condoms) is recommended for 30 days after starting treatment or after any dose increase.
• Not recommended while breastfeeding.
• Tell your prescriber before starting if you have ever had pancreatitis, gallbladder problems, severe digestive problems, diabetic eye disease, or severe heart failure.
• If you also take insulin or a sulfonylurea, your doctor may lower that dose to reduce the risk of low blood sugar (hypoglycaemia).
• If you take medicine to lower your blood pressure, tell your doctor before starting Foundayo.
• Nausea, vomiting or diarrhoea can cause dehydration. Make sure you drink enough fluids while taking Foundayo, as dehydration can affect your kidneys.
• If you have surgery planned, tell your medical team that you are taking Foundayo.
• Tell your prescriber about all other medicines you take. Some, such as clarithromycin, itraconazole or ritonavir, can increase orforglipron levels, while others, such as carbamazepine, rifampicin or St John's wort, can make it less effective.
• Not licensed for use in anyone under 18.
• Foundayo is a new medicine subject to additional monitoring. Report any side effects you experience to your doctor or pharmacist.

Very common (more than 1 in 10 people): nausea, constipation, diarrhoea, vomiting, indigestion and stomach (abdominal) pain. Low blood sugar (hypoglycaemia) is also very common if you also take insulin.

Common (up to 1 in 10 people): dizziness, headache, a fast heartbeat, low blood pressure, bloating, acid reflux, gallstones, hair loss and tiredness. Low blood sugar is common if you also take a sulfonylurea.

Uncommon (up to 1 in 100 people): inflamed pancreas (acute pancreatitis), which causes severe stomach or back pain that does not go away. Seek medical attention if this happens. A change in taste and unusual skin sensations, such as tingling, can also occur, as can low blood sugar even without insulin or a sulfonylurea.

These are not all the possible side effects. If you notice any side effect not listed here, or any side effect becomes serious, tell your doctor or pharmacist.